Monday, September 27, 2010

why does benzene lead to hemolysis of red blood cell?

RBCs have a phospholipid membrane close to other cells of the body. Lipids are soluble within alcohols like benzene, so the membrane falls apart.
Hemolysis (or haemolysis)—from the Latin Hemo-, worth blood, -lysis, meaning to break open— is the breaking unseal of red blood cells and the release of hemoglobin into the surrounding fluid (plasma, contained by vivo).
The major effect of benzene from chronic (long-term) exposure is to the blood. Benzene damages the bone marrow and can result in a decrease surrounded by red blood cells, central to anemia. It can also cause excessive bleeding and depress the immune system, increasing the accident of infection
Benzene is no longer used as an additive surrounded by gasoline but it is an important industrial solvent and precursor contained by the production of drugs, plastics, synthetic rubber, and dyes.
I dont know if this will help but as of very soon it is all I can find.
This might aid
http://iuhs-isa.org/usmle/hematologic/he.

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