Above answers deal more beside heart transplants, which are mostly affected by autoimmune issues. If you are asking more or less artificial hearts made of synthetic substance, the most important problem is clotting. Our blood in reality wants to clot adjectives the time. Out arteries are covered with substances that prevent that. It is exceedingly difficult to apply those substances to the synthetic heart and thus clotting is the key problem. Here is the website that deals near that stuff:
http://www.heartpioneers.com/
Your body will reject it-thats it. Its so complicated you would think, but in attendance are not enough antibiotics to put in the picture the body to accept an artificial heart.
its be hard to return with the persons body to adopt it, and not treat it as a foriegn object, cuz if it does, consequently it will attack it and kill the modern heart. they are coming out with cloning organs, so every soul can have an exact replica of their organs made if they necessitate it for surgery.
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